How to understand the chemical composition of essential oils

Learn more about the main chemical families present in essential oils: aldehydes, esters, ethers, ketones, monoterpenes, oxides, phenols, sesquiterpenols and more...

Understanding the basic chemical families of essential oils helps us better understand their therapeutic properties and safe use. While it's not always possible to assign identical effects to all members of a given family, knowing their general characteristics can provide valuable guidance when choosing the right oil.

We also recommend that you thoroughly familiarize yourself with the chemical composition of each oil (available in the GC/MS reports on our website) and its uses, benefits and safety guidelines.

Aldehydes

Therapeutic properties:

  • Strong antifungal effect – recommended for combination with soothing oils, e.g. sandalwood or lavender.
  • Anti-inflammatory and antispasmodic.
  • Antibacterial and tonic for the nervous system.
  • Cooling effect.

Safety rules:

  • Oils rich in aldehydes can irritate the skin, especially after oxidation.
  • Citral (geranial and neral) may be irritating to skin and mucous membranes.
  • Use in low concentrations: 5-6 drops per 30 ml of carrier oil.
  • Store oils with a high aldehyde content in tightly closed bottles in a dark and cool place.
  • People with hormone-dependent cancers should avoid long-term use.

Examples of oils rich in aldehydes:

  • Java citronella oil ( Cymbopogon winterianus )
  • Lemongrass oil ( Cymbopogon flexuosus )
  • Lemon balm oil ( Melissa officinalis )

Esters

Therapeutic properties

  • Antispasmodic – ranging from mild to strong. Many aromatherapists consider isobutylangelate (found in Roman chamomile) to be one of the best antispasmodic ingredients.
  • Calming, balancing, and soothing—regulating the autonomic nervous system. Oils rich in esters often have uplifting properties and are known as "balancing components."
  • Analgesics (e.g. Roman chamomile, lavender, ylang-ylang).
  • Digestive Support – Some esters are helpful in digestion, such as those found in cardamom, Roman chamomile, and bergamot oils.
  • Anti-inflammatory – soothes skin irritations and rashes.
  • Adaptogenic – support stress management.

Precautions

  • Usually safe for skin.
  • Exception: methylsalicylate (e.g. in wintergreen) may cause irritation.

Popular essential oils rich in esters

  • Bergamot essential oil ( Citrus bergamia )
  • Cardamom essential oil ( Elettaria cardamomum )
  • Clary sage essential oil ( Salvia sclarea )
  • Jasmine essential oil ( Jasminum sambac )
  • Lavender essential oil ( Lavandula angustifolia )
  • Roman chamomile essential oil ( Chamaemelum nobile )
  • Rose and geranium essential oil ( Rosa x damascena / Pelargonium x asperum )
  • Wintergreen ( Gaultheria fragrantissima ) essential oil

Ethers

Therapeutic properties:

  • Antispasmodic action
  • Supporting digestive health.

Precautions:

  • They may irritate the skin.
  • Use at higher doses may raise toxicity concerns – Recommended use at low concentrations (<1%) and only for emergency, short-term applications.
  • Avoid during pregnancy and long-term use.

Examples of essential oils with a high ether content:

  • Anise essential oil (Pimpinella anisum)
  • Fennel essential oil (Foeniculum vulgare)

Ketones

Therapeutic properties:

  • Mucolytic, expectorant, analgesic action.
  • Some oils rich in ketones may support the healing of scars and wounds, such as lavender and vetiver.
  • Peppermint, rosemary, camphor, and lavender may affect circulation.

Precautions:

  • Ketones are different – they do not have identical therapeutic properties or the same safety restrictions, so each ingredient should be considered individually.
  • Non-toxic ketones include menthone, verbenone, vetivone, fenchone, carvone, piperitone, jasmone, and tumerone.
  • Some oils containing camphor (e.g., rosemary, camphor, lavender) may raise safety concerns.
  • Camphor oils should not be used by people suffering from epilepsy, pregnant women, or people with high fever.
  • Camphor-containing preparations should not be applied near the noses of infants and young children. Camphor ingestion by children can be fatal – just four teaspoons constitutes a lethal dose!
  • Camphor can cause convulsions both when taken orally and, less frequently, when inhaled.
  • Camphor can cause miscarriage, though only in near-lethal doses.
  • Oils containing camphor should only be used for short periods and in small amounts.
  • As a general rule, ketones should constitute a maximum of 1% in 30 ml of an essential oil blend.
  • Ketones are more difficult to metabolize by the liver and can accumulate, raising concerns about long-term use at high doses. People with liver disease should use minimal amounts of ketone-rich oils.
  • Camphor is a stimulant of the central nervous system (CNS), but in excess it can lead to CNS depression.

Examples of essential oils high in ketones:

  • Peppermint essential oil (Mentha x piperita)
  • Rosemary essential oil ct camphor (Rosmarinus officinalis ct camphor)
  • Lavender essential oil (Lavandula latifolia)
  • Turmeric essential oil (Curcuma longa)
  • Vetiver essential oil (Vetiveria zizanoides)

Monoterpenes

Therapeutic properties

  • Mild antiseptic properties.
  • Effective expectorant action supporting the respiratory and muscular systems.
  • The warming effect (rubefacient) improves circulation and relieves muscle pain and stiffness.
  • Some oils rich in monoterpenes have anti-inflammatory properties.
  • Mild antibacterial action – some may also have antiviral properties.
  • High lipophilicity – they easily penetrate body tissues (penetration enhancers).
  • Effective as deodorants and air purifiers.
  • They improve overall health.

Precautions

Oils high in monoterpenes may cause skin irritation or allergic reactions if oxidized. It's important to store them tightly closed in a cool, dark place.

Monoterpenes are not water-soluble, so avoid using them in baths unless well diluted in a carrier oil. Studies have shown that the monoterpene limonene can be a potential allergen and irritant if oxidized.

Commonly used essential oils with high monoterpene content

  • Balsam fir essential oil ( Abies balsamea )
  • Bergamot essential oil ( Citrus bergamia )
  • Black pepper essential oil ( Piper nigrum )
  • Black spruce essential oil ( Picea mariana )
  • Cypress essential oil ( Cupressus sempervirens )
  • Juniper berry essential oil ( Juniperus communis )
  • Scots pine essential oil ( Pinus sylvestris )
  • Siberian fir ( Abies sibirica ) essential oil
  • Tea tree essential oil ( Melaleuca alternifolia )
  • White pine essential oil ( Pinus strobus )
  • White spruce essential oil ( Picea glauca )

Monoterpenols

Therapeutic properties

  • Essential oils containing a high alcohol content have strong antibacterial, antifungal and sometimes antiviral effects.
  • Non-toxic and gentle to skin and mucous membranes.
  • They support the immune system with long-term use.
  • Studies show that linalool is effective against bacteria, and geraniol fights fungi. Terpinen-4-ol in tea tree oil activates white blood cells, helping fight infections.
  • Ingredients like menthol, linalool, alpha-terpineol, and geraniol provide a cooling sensation at the application site and have a local anesthetic effect. Linalool also has strong sedative properties, making oils like lavender and rosewood beneficial in blends for insomnia.
  • Oils rich in monoterpenols are valuable in skincare – they have antiseptic and sometimes anti-inflammatory properties. They are generally safe and support skin regeneration.
  • They tone the nervous system.
  • They support emotional balance.
  • They strengthen the immune system by detoxifying the body.
  • Blends containing geranium, lavender or bergamot have a natural deodorizing effect because they inhibit the growth of bacteria.
  • Oils rich in monoterpenols have antispasmodic properties and relieve muscle tension – especially geraniol, linalool, menthol, citronellol and borneol.

Precautions

  • Most oils rich in monoterpenols are safe for skin and do not cause irritation. The exception is peppermint, which may cause irritation.
  • Menthol-rich oils should not be used on children under 5 years of age and should be avoided around infants.
  • People who should avoid antimalarial drugs, sulfonamides, chloramphenicol, streptomycin, or aspirin should not use menthol-rich oils.
  • Geraniol (found in palmarosa, geranium, citronella, rose, fingerroot, and thyme) may cause mild allergic skin reactions. Do not exceed a maximum concentration of 5.3% for dermal application.
  • Robert Tisserand emphasizes that studies show no allergic reactions to linalool in healthy individuals. Linalool also exhibits broad anticancer effects at the cellular level.

Commonly used essential oils rich in monoterpenols

  • Nutmeg sage (Salvia sclarea)
  • Fingerroot (Boesenbergia pandurata)
  • Fragonia (Agonis fragrans)
  • Geranium and rose (Rosa x damascena / Pelargonium x asperum)
  • Lavender (Lavandula angustifolia)
  • Neroli (Citrus aurantium var. amara)
  • Palmarosa (Cymbopogon martinii var. motia)
  • Peppermint (Mentha x piperita)
  • Petitgrain (Citrus aurantium var. amara or bigaradia)
  • Absolute rose (Rosa x damascena)
  • Broadleaf lavender (Lavandula latifolia)
  • Sweet marjoram (Origanum majorana)
  • Tea tree (Melaleuca alternifolia)

Oxides

Therapeutic properties

  • Essential oils rich in oxides can be very effective in treating respiratory diseases.
  • Oils containing large amounts of 1,8-cineole (except German chamomile) have antiviral, antifungal and antibacterial effects.
  • 1,8-cineole stimulates the glands of the respiratory system. It has an expectorant and mucolytic effect, stimulating mucus-secreting cells and activating the cilia of the respiratory mucosa.
  • 1,8-cineole stimulates mental processes and increases blood flow to the brain when inhaled.
  • Studies have shown that 1,8-cineole has an anti-inflammatory effect on bronchial asthma, reduces cough, shortness of breath and facilitates expectoration.
  • 1,8-cineole improves skin penetration, but also has a drying effect.
  • 1,8-cineole has an analgesic and anti-inflammatory effect on the muscles and respiratory system.
  • The oxides contained in German chamomile have anti-inflammatory and muscle-relaxing properties.

Precautions

  • Caution should be exercised when using 1,8-cineole in asthmatics, as it may trigger an asthma attack. This reaction is individual and depends on the oil, dose, application method, and situation.
  • Do not use on infants. Use with caution in children under 10 years of age.
  • If oxidized, it may cause skin irritation and hypersensitivity.

Common oxide-rich essential oils

  • Cardamom essential oil ( Elettaria cardamomum )
  • Eucalyptus globulus essential oil
  • Fragonia essential oil ( Agonis fragrans )
  • Ravintsara essential oil ( Cinnamomum camphora 1.8 cineole )
  • Rosalina essential oil ( Melaleuca ericifolia )
  • Broad-leaved lavender essential oil ( Lavandula latifolia )

Phenols

Therapeutic properties

  • Essential oils containing high levels of phenols are strongly anti-infective and are used for acute infections. (For long-term infections, it's better to use oils rich in monoterpenols.)
  • They have a warming effect ( rubefacient ) – they increase local blood circulation, cause slight skin irritation, dilate blood vessels and have a local analgesic effect.
  • When combined with other oils with skin regenerating properties, they can have an anti-inflammatory effect.
  • Used for acute illnesses and infections to stimulate the immune system.

Precautions

  • Oils rich in phenols are the most irritating to the skin and mucous membranes – they can cause dermatitis and hypersensitivity.
  • If the oil contains a high concentration of phenols, it should be applied to the skin in very low concentrations and for short periods of time.
  • They are not safe for bathing if used in high concentrations.
  • When mixing oils for diffusion, they should not constitute more than 1% of the mixture.
  • Do not use on infants and children.
  • Clove oil ( Eugenia caryophyllata ) is not recommended for people with blood clotting disorders because it contains eugenol, an ingredient with anticoagulant properties.

Common phenol-rich essential oils

  • Cinnamon leaf essential oil ( Cinnamomum zeylanicum )
  • Clove bud essential oil ( Eugenia caryophyllata )
  • Oregano essential oil ( Origanum vulgare )
  • Tulsi (Holy Basil) Essential Oil ( Ocimum sanctum ct eugenol )

Sesquiterpenes

Therapeutic properties

  • In the case of sesquiterpenes, the therapeutic effects of each oil must be considered individually, as they cannot be generalized as easily as most other chemical families.
  • Oils high in sesquiterpenes may have anti-inflammatory, antibacterial, antiseptic, analgesic, and antispasmodic properties.
  • Even a small amount of sesquiterpenes in the carrier oil can have a strong therapeutic effect.

Precautions

  • Sesquiterpene-rich oils typically have no safety concerns. However, black pepper may cause irritation in people with sensitive skin, and some sesquiterpenols can become irritating to the skin if oxidized.
  • According to Tisserand, β-elemene, found in myrrh, has antiangiogenic properties, meaning it inhibits the formation of new blood vessels. This may help prevent tumor growth, but it can also inhibit fetal growth—therefore, it should be avoided during pregnancy.

Popular essential oils high in sesquiterpenes

  • Copaiba Balsam Oleoresin (Copaifera officinalis)
  • Black pepper essential oil (Piper nigrum)
  • Virginian Cedar (Juniperus virginiana) Essential Oil
  • Ginger essential oil (Zingiber officinale)
  • Manuka essential oil (Leptospermum scoparium ct east cape)
  • Lemon balm essential oil (Melissa officinalis)
  • Myrrh essential oil (Commiphora myrrha)
  • Patchouli essential oil (Pogostemon cablin)
  • Rhododendron essential oil (Rhododendron anthopogon)
  • Vetiver essential oil (Vetiveria zizanoides)
  • Ylang-ylang essential oil (Cananga odorata var genuina)

Sesquiterpenols

Therapeutic properties

  • The therapeutic properties of sesquiterpenols can vary significantly because their components have unique effects.
  • Many oils rich in sesquiterpenols have grounding, antispasmodic, antibacterial, skin-healing, and anti-inflammatory properties.
  • Some oils provide long-term support for the body, act as tonics for the veins and lymphatic system, and stimulate the immune system.

Precautions

  • Sesquiterpenols are generally safe and are not known to be skin irritants.
  • If you are taking anticoagulants, have stomach ulcers, or a blood clotting disorder, avoid oils containing β-eudesmol, such as blue cypress.
  • Some sesquiterpenols may have antiangiogenic effects, meaning they inhibit the formation of new blood vessels – they should not be used during pregnancy.

Popular essential oils high in sesquiterpenols

  • Carrot seed essential oil (Daucus carota)
  • Virginian Cedar (Juniperus virginiana) Essential Oil
  • German chamomile essential oil (Matricaria recutita)
  • Ginger essential oil (Zingiber officinale)
  • Patchouli essential oil (Pogostemon cablin)
  • Sandalwood essential oil (Santalum album)
  • Vetiver essential oil (Vetiveria zizanoides)
Source: Aromatics International.
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